Mathew R. Schnorenberg, Katrina M. Hawley, Anika T. Thomas-Toth, Elyse A. Watkins, Yu Tian, Jeffrey M. Ting, Logan B. Leak, Isadora M. Kucera, Michal M. Raczy, Andrew L. Kung, Jeffrey A. Hubbell, Matthew V. Tirrell, James L. LaBelle (2023) Targeted polymersome delivery of a stapled peptide for drugging the tumor protein p53:BCL-2-family axis in diffuse large B-cell lymphoma. ACS Nano.17, 23:23374-23390. Schnorenberg et al. 2023
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Akshay Sharma, MBBS, Jaap-Jan Boelens, MD, PhD, Maria Cancio, MD, Jane S. Hankins, MD, MS, Prafulla Bhad, MSc, Andrew Lewandowski, PhD, Xiaojun Zhao, PhD, Shripad Chitnis, PhD, Radhika Peddinti, MD, Yan Zheng, MD, PhD, Neena Kapoor, MD, Fabio Ciceri, MD, Timothy Maclachlan, PhD, Yi Yang, PhD, Yi Liu, PhD, Jianping Yuan, PhD, Ulrike Naumann, MS, Vionnie Yu, PhD, Susan C. Stevenson, PhD, Serena De Vita, MD, PhD, James L. LaBelle, MD, PhD (2023) CRISPR-Cas9 Editing of the HBG1/HBG2 Promoters to Treat Sickle Cell Disease. N Engl J Med. 389:820-832. Sharma et al. 2023
Saygin, C., Eisfelder, B., Giordano, G., Shimamoto, K., Thomas-Toth, A., Venkataraman, G., Ananthanarayanan, V., Vincent, T.L., DuVall, A., Patel, A.A., Chen, Y., Tan, F., Anthony, S.P., Chen, Y., Shen, Y., Olatoyosi, O., Teachey, D., LaBelle, J.L.*, Stock, W.* (equal contributions) (2023). Dual targeting of apoptotic and signaling pathways in T-lineage acute lymphoblastic leukemia. Clinical Cancer Research. Jun 26, CCR-23-0415. Saygin et al. 2023
LaBelle, J.L. (2023) Small but mighty: T-replete cord transplantation for myeloid disease in children. Blood Advances. 7(10):2153-2154. LaBelle, J.L. 2023
Hawley, K.M., Eclov, R.J., Schnorenberg, M.R., Tian, Y., Shaw, R.N., Thomas-Toth, A.T., Fefferman, M., Bird, G.H., Walensky, L.D., Tirrell, M.V., LaBelle, J.L. (2022) Inhibition of FOXP3 Dimerization by stapled alpha-helical peptides dampens regulatory T cell function. PNAS. October 13. Hawley et al. 2022
Tran, M.C., Aydogan, B., Hasan, Y., Wang, A., Yenice, K., Partouche, J., Stock, W., Larson, R.A., Kosuri, S., LaBelle, J.L., Kline, J., Riedell, R.A., Artz, A.S., Weichselbaum, R., Bishop, M.R., Liu, H. (2022) A phase I trial utilizing TMI with fludarabine-melphalan in patients with hematologic malignancies undergoing second also-SCT. Blood Advances. Jul 18. Tran et al. 2022
Desai, A.V., Applebaum, M.A., Karrison, T. Oppong, A., Yuan, C., Berg, K., MacQuarrie, K., Sokol, E., Gollapudi, A., Pinto, N.R., Wolfe, I., Mody, R., Shusterman, S., Smith V., Foster, J., Nassin, M., LaBelle, J.L., Bagatell, R., Cohn, S.L. (2022) Efficacy of Post-Induction Therapy for High-Risk Neuroblastoma Patients with End-Induction Residual Disease. Cancer. 128(15): 2967-2977. Desai et al. 2022
*Editorial A bridge over troubled water-
Tian, Y., Tirrell, M.V. LaBelle, J.L. (2022) Harnessing the Therapeutic Potential of Biomacromolecules Through Intracellular Delivery of Nucleic Acids, Peptides and Proteins. Advanced Healthcare Materials. March 14. Tian et al. 2022
*Featured in Hot Topic: Drug Delivery ChemMedChem Hot topic:Drug Delivery
McKee, M.N, Palama, B.K., Hall, M., LaBelle, J.L., Bohr, N.L., Hoehn, S. (2022) Racial and Ethnic Differences in Inpatient Palliative Care for Pediatric Stem Cell Transplant Patients. Pediatric Critical Care Medicine. McKee et al. 2022
Khanna, S., Mackin, A.G., Dao, D.T., Komati, R., Morocco, P.C., LaBelle, J.L., Shah, H.A., Blair, M.P. (2022) Exudative Retinal Detachment Following Chimeric Antigen Receptor T-Cell Therapy in Relapsed Acute Lymphoblastic Leukemia. Ophthalmic Sure Lasers Imaging Retina. Khanna, et al. 2022
Ludwig, L.M., Hawley, K.L., Banks, D.B., Thomas-Toth, A.T., McNearny, M.E., Blazar, B., Leverson, J.D., LaBelle, J.L. (2021) Venetoclax Imparts Distinct Cell Death Sensitivity and Adaptivity Patterns in T cells. Cell Death & Disease. 12:1005. Ludwig, et al. 2021
Volpatti, L.R., Wallace, R.P., Can, S., Raczy, M.M., Wang, R., Gray, L.T., Alpar, A.T., Briquez, P.S., Mitrousis, N., Marchell, T.M., Sasso, M.S., Mansurov, A., Budina, E., Solanki, A., Watkins, E.A., Schnorenberg, M.R., Tremain, A.C., Reda, J.W., Nicolaescu, V., Furlong, K., Dvorkin, S., Yu, S.S., Manicassamy, B., LaBelle, J.L., Tirrell, M.V., Randall, G., Kwissa, M., Swartz, M.A., Hubbell, J.A. (2021) Polymersomes decorated with SARS-CoV-2 spike protein receptor binding domain elicit robust humoral and cellular immunity. ACS Central Science. 7(8):1368-1380. Volpatti, et al. 2021
Harris, K., LaBelle, J.L., Bishop, M.R. (2021) Current Status of CAR T-Cell Therapy for Leukemias. Current Treatment Options in Oncology. 22(7):65. Harris, et al. 2021
Siddiqui, A., Pinto, N., Applebaum, M.A., Cunningham, J.M., LaBelle, J.L., Nassin, M.L. (2021) The Addition of Autologous Stem Cell Transplantation to Neo-Adjuvant Chemotherapy, Radiation, and HIPEC for Patients with Unresectable Desmoplastic Small Round Cell Tumor: A Single Center Case Series. International Journal of Surgery: Oncology. 5.e95. Siddiqui, et al. 2021
Ludwig, L.M., Roach, L.E., Katz, S.G., LaBelle, J.L. (2020) Loss of BIM in T Cells Results in BCL-2 Family BH3-member Compensation but Incomplete Cell Death Normalization. Apoptosis. 25:247-260. Ludwig, et al. 2020
Kothari, S., Artz, A.S., Lee, S.M., Fulton, N., Park, J-H., Stock, W., Larson, R.A., Odenike, O., Kline, J., LaBelle, J., Kosuri, S., Riedell, P., Nakamura, Y., Bishop, M.R., Liu, H. (2020) Dose Escalation Prophylactic Donor Lymphocyte Infusion After T-cell Depleted Matched Related Donor Allogeneic Hematopoietic Cell Transplantation Is Feasible and Results in Higher Donor Chimerism, Faster Immune Re-constitution, and Prolonged Progression-Free Survival. Bone Marrow Transplantation. 10:1038; ahead of print. Kothari, et al. 2020
Hadji, A., Schmitt, G. K., Schnorenberg, M. R., Roach L., Hickey, C.M., Leak, L.B., Tirrell, M.V., LaBelle, J.L. (2019) Preferential Targeting of MCL-1 by a Hydrocarbon-Stapled BIM BH3 Peptide. Oncotarget. 10:6219-6233. Hadji, et al. 2019
Schnorenberg, M.R.*, Bellairs, J.A.*, Samaeekia, R., Acar, H., Tirrell, M. V., LaBelle, J.L. (2019) Activating the Intrinsic Pathway of Apoptosis Using BIM BH3 Peptides Delivered by Peptide Amphiphiles with Endosomal Release. Materials. 12(16). 2567. Schnorenberg and Bellairs, et al. 2019
Fan Y., Artz, A.S., van Besien, K., Stock, W., Larson, R.A., Odenike, O., Godley, L.A., Kline, J., Cunningham, J.M., LaBelle, J.L., Bishop, M.R., Liu, H. (2019) Outcomes Following Second Allogeneic Stem Cell Transplantation for Disease Relapse after T Cell Depleted Transplant Correlate with Remission Status and Remission Duration after the First Transplant. Experimental Hematology & Oncology. 8:1. Fan, et al. 2019
Ludwig, L.M., Maxcy, K., LaBelle, J.L. (2019) Flow cytometry-based detection and analysis of BCL-2 family proteins and mitochondrial outer membrane permeabilization (MOMP). Methods in Molecular Biology. 1877:77-91. Ludwig, et al. 2019
Schnorenberg, M.R., Yoo, Sang Pil, Tirrell, M.V., LaBelle, J.L. (2018) Synthesis and purification of homogenous lipid-based peptide nanocarriers by overcoming phospholipid ester hydrolysis. ACS Omega. 3(10):14144-14150. Schnorenberg, et al. 2018
Nassin, M.L., Nicolaou, E., Gurbuxani, S., Cohn, S.L., Cunningham, J.M., LaBelle, J.L. (2018) Immune reconstitution following autologous stem cell transplantation in patients with high-risk neuroblastoma at the time of ch14.18 mAb immunotherapy. Biology of Blood and Marrow Transplantation. 24(3):452-459. Nassin, et al. 2018
Acar, H., Ting, J.M., Srivastava, S., LaBelle, J.L.,Tirrell, M.V. (2017) Molecular Engineering Solutions for Therapeutic Peptide Delivery. Chemical Society Reviews. 46(21):6553-6569. Acar, et al. 2017
Acar, H., Samaeekia, R., Schnorenberg, M. R., Tirrell, M. V., LaBelle, J.L. (2017) Cathpesin-mediated cleavage of peptides from peptide amphiphiles leads to enhanced intracellular peptide accumulation. Bioconjugate Chemistry. 28(9): 2316-2326. Acar, et al. 2017
Pu, Jinyue, Dewey, J.A., Hadji, A., LaBelle, J.L.,Dickinson, B.C. (2017) RNAP tags to monitor multidimensional protein-protein interactions reveal pharmacological engagement of Bcl-2 proteins. Journal of the American Chemical Society. 139(34):11964-11972. Pu, et al. 2017
Nassin, M., Virgilio, J., Heeney, M., LaBelle, J.L. (2017) Neonatal Anemia: Revisiting the Enigmatic Pyknocyte. American Journal of Hematology. 92(7):717-721. Nassin, et al. 2017
Ludwig, L., Nassin, M., Hadji, A., LaBelle, J.L. (2016) Killing Two Cells with One Stone: Pharmacologic BCL-2 Family Targeting for Cancer Cell Death and Immune Modulation. Frontiers in Pediatrics; Pediatric Hematology and Hematological Malignancies. 4:135. Ludwig, et al. 2016
Acar, H., Srivastava, S., Chung, E., Schnorenberg, M.R., Barett, J.C., LaBelle, J.L.,Tirrell. (2016) Self-Assembling Peptide-Based Building Blocks in Medical Applications. Advanced Drug Delivery Reviews. 110-111:65-79. Acar, et al. 2016
Darlington, W.S., Pinto, N., Hecktman, H., Cunningham, J.M., Cohn, S.L., LaBelle, J.L. (2015) Stem Cell Transplant-Associated Wernicke Encephalopathy in a Patient with Stage 4, High-Risk Neuroblastoma. Pediatric Blood and Cancer. 62(12):2232-2234. Darlington, et al. 2015
Diamond, C. E., Sanchez, M.J., LaBelle, J.L. (2015) Diagnostic Criteria and Evaluation of Severe Combined Immunodeficiency in the Neonate. Pediatric Annals. 44(7):181-187. Diamond, et al. 2015
Reynolds, C., Roderick, J., LaBelle, J.L., Bird, G., Mathieu, R., Bodaar, K., Colon, D., Pyati, U., Stevenson, K., Qi, J., Harris, M., Silverman, L., Sallan, S., Bradner, J.E., Neuberg, D.S., Look, A.T., Walensky, L., Kelliher, M.A., Gutierrez, A. (2014) Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia. Leukemia. 28:1819-1827. Reynolds, et al. 2014
Bird, G., Gavathiotis, E., LaBelle, J.L., Katz, S.G., Walensky, L.D. (2014) Distinct BimBH3 (BimSAHB) Stapled Peptides for Structural and Cellular Studies. Journal of the American Chemical Society. 9(3):831-837. Bird, et al. 2014
Katz, S.G., LaBelle, J.L., Valeriano, R.P., Fisher, J.K., Walensky, L.D. (2014) Mantle Cell Lymphoma in Cyclin D1 Transgenic Mice with Bim-deficient B-cells. Blood.123 (6):884-893. Katz, et al. 2014
Meserve, EE, Lehmann, L., Perez-Atayde, A.R., LaBelle, J.L. (2014) Cyclophosphamide-Associated Cardiotoxicity in a Child following Stem Cell Transplantation for β-Thalassemia Major: Case Report and Review of the Literature. Pediatric Developmental Pathology. 17(1):50-54. Meserve, et al. 2014
LaBelle, J.L.and Cunningham, J.M. (2013) Stem Cell Transplant as an Immunomodulatory Tool for Children with Hematological Malignancies. ASCO Educational Book. e347. LaBelle and Cunningham. 2013
Edwards, A. L., Gavathiotis, E., LaBelle, J.L.,Braun, C. R., Opoku-Nsiah, K., Bird, G.H., Walensky, L.D. (2013) Multimodal Interaction with BCL-2 Family Proteins Underlies the Proapoptotic Activity of PUMA BH3. Chemistry & Biology. 20:888-902. Edwards, et al. 2013
LaBelle, J.L.,Katz, S.G., Bird, G.H., Gavathiotis, E., Stewart, M.L., Lawrence, C., Fisher, J.K., Godes, M., Pitter, K., Kung, A.L., Walensky, L, D. (2012) A Stapled BIM Peptide Overcomes Apoptotic Resistance in Hematologic Cancers. Journal of Clinical Investigation. 122(6):2018-2031.
Pitter, K., Bernal, F., LaBelle, J.,Walensky, L.D. (2008) Dissection of the BCL-2 Family Signaling Network by Use of Stabilized a-Helices of BCL-2 Domains. Methods in Enzymology. 446:387-408. Pitter, et al. 2008
Gutweiler, J., LaBelle, J., Suh, M., Misra, M., Ahmed, M., Lee, E., Vargas, S., Kim, H., Weldon, C. (2008) A Familial Case of Pleuropulmonary Blastoma. European Journal of Pediatric Surgery. 18:192-194. Gutweiler, et al. 2008
Fishman, D.S, Manfredi, M.A, LaBelle, J.L, Levine, J.E., Shamberger, R.C., Rufo, P.A. (2007) Pancreatitis as the Initial Manifestation of Stage IV Neuroblastoma-A Case Report. Journal of Pediatric Gastroenterology and Nutrition. 44:146-148. Fishman, et al. 2007
Rosenblum, M. D., LaBelle, J.L., Chang, C.C., Margolis, D. A., Schauer, D. W., Vesole, D. H. (2004) Efficacy of Alemtuzumab Treatment for refractory T Cell Large Granular Lymphocytic Leukemia. Blood. 103(5);1969-1971. Rosenblum, et al. 2004
LaBelle, J.L. and Truitt, R.L. (2002) Characterization of a Murine NKT Cell Tumor Previously Described as an Acute Myelogenous Leukemia. Leukemia and Lymphoma. 43(8):1637-1644. LaBelle, et al. 2002b
LaBelle, J.L., Hanke, C.A., Blazar, B.R., Truitt, R.L. (2002) Negative Effect of CTLA-4 In Vivo on Induction of T-cell Immunity to B7-1+, but not B7-2+, Murine Acute Myelogenous Leukemia. Blood. 99(6):2146-2153. LaBelle, et al. 2002a
Johnson, B.D., Becker, E.B., LaBelle, J.L., Truitt, R.L. (1999) Role of Immunoregulatory Donor T Cells in Suppression of Graft-Versus-Host Disease Following Donor Leukocyte Infusion Therapy. Journal of Immunology. 163:6479-6487. Johnson, et al. 1999
LaBelle, J. L., Dutton, K.G., Maravolo, N.C. (1997) The Influence of Ethylene and Spermine on Phosphatase Activity During Senescence in Marchantia Polymorpha. International Journal of Plant Science. 158:552-555. LaBelle, et al. 1997